NEWS

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RIDE ACROSS BRITAIN FOR CRUK

18 September 2022

Sarah completed her end-to-end bike ride of the UK, from Lands End to John O'Groats in September. 

The final tally was: • 978 miles / 1574 kilometres • 56,931 feet climbed • 9 days • 2 wheels • 1 tent • 39 bananas • 0 punctures

Thanks to generous sponsorship from friends, family, and colleagues I reached my fundraising target for Cancer Research UK.


Any final donations are of course welcome!

https://www.justgiving.com/fundraising/SJA-LEJOG-2022

Please remember to add Gift Aid if you are eligible - thank you! 

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EUROPEAN CONGRESS OF PATHOLOGY
BASEL, SWITZERLAND

07 September 2022

John Connelly and Jose Coelho-Lima both gave talks this week at the European Congress of Pathology in Basel, Switzerland.

Here is a glimpse of John's brilliant talk on "Predicting genetic variation from quantitative tissue phenotypes using explainable machine learning".

Jose presented his clinical project "Cardiac arrest with successful cardiopulmonary resuscitation induces histologic changes that correlate with survival time and lead to misdiagnosis in sudden arrhythmic death syndrome"

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CAMBRIDGE BIOSCIENCES DTP SYMPOSIUM

25 July 2022

Hashim Ahmed Nur attended the Cambridge Biosciences DTP Symposium. 

Busy Conference

HELLO AND GOODBYE!

30 June 2022

Today we said goodbye to Jose Coelho-Lima, who has finished his NIHR Academic Clinical Fellowship with us, and heading back to clinical work (for now). 

We also welcomed John Connelly to the lab, who is joining us from Prof. Martin Taylor's lab at our sister Unit, the MRC Human Genetics Unit in Edinburgh.

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PULMONARY PATHOLOGY SOCIETY MEETING, CORK, IRELAND

27 June 2022

Jose Coelho-Lima attended the Pulmonary Pathology Society meeting in Cork. 

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EUROPEAN CONGRESS ON DIGITAL PATHOLOGY (ECDP). BERLIN, GERMANY

16 June 2022

John Connelly attended the European Congress on Digital Pathology in Berlin.


His work was selected for an oral presentation: "Using machine learning to infer whole genome duplication from tumour nuclear morphology".

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NEW PREPRINT: STRAND-RESOLVED MUTAGENICITY OF DNA DAMAGE AND REPAIR

10 June 2022

Strand-resolved mutagenicity of DNA damage and repair

We recently discovered that some DNA lesions (damaged bases) segregate unrepaired into daughter cells for multiple generations, thereby generating combinatorial genetic diversity (Aitken et al., 2020). We have now leveraged this discovery to learn more about how strand-asymmetric processes, such as replication and transcription, shape DNA damage and repair (Anderson et al., 2022).

Read the preprint here.

Read Sarah's tweetorial here.

#StrandInteractions

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EMBO CANCER EVOLUTION
RIMINI, ITALY

20 May 2022

Sarah was invited to the EMBO Workshop: The many faces of cancer evolution to present unpublished work from the LCE Consortium "Disentangling strand interactions in DNA damage and repair".

#StrandInteractions

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IRB BARCELONA, INVITED SEMINAR

27 April 2022

Sarah was invited to deliver the IRB Barcelona Research Seminar for the Computational Biology and Preclinical Models of Cancer research nodes. 

"Disentangling strand interactions in DNA damage and repair"

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WE ARE HIRING: COMPUTATIONAL POSTDOC

14 April 2022

We are hiring: Postdoctoral researcher (Research Associate) in Computational Biology or Bioinformatics to join us summer/autumn 2022. 

Deadline: 28 April 2022

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CONTRA CONFERENCE, ANDERMATT

12 April 2022

Sarah was invited to present at the Computational Oncology Conference organised by CONTRA (Computational ONcology TRaining Alliance Innovative Training Network). 

"Re-running cancer evolution in vivo to disentangle DNA damage and repair"

First in-person conference since the pre-COVID era. Enthusiastic and engaged participants. And great snow...

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MEDICAL MASTERCLASSES

07 April 2022

During the Cambridge Festival 2022, two of our lab members were invited by the Department of Pathology to give Medical Masterclasses aimed at Year 12 pupils from all backgrounds interested in medicine (not just at Cambridge), followed by a Q&A with current medical students. 


Jose Coelho-Lima, our Academic Clinical Fellow, discussed the role of artificial intelligence in medicine and clinical research. 


And Sarah talked about "Putting pathology under the microscope".

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FIRST YEAR PHD TALKS

23 March 2022

Hashim, and all of the other first year PhD students at the MRC Toxicology Unit presented an overview of their project to the other students and group leaders. Well done!

Embryonic Stem Cells

LANDS END TO JOHN O'GROATS FOR CRUK

20 February 2022

Sarah is cycling from Lands End to John O'Groats in September

• 970miles • 1552km • 9 days • 2 wheels • 1 tent •

Although I am a daily, all-weather cyclist, this will be a massive challenge - so I've signed up via Cancer Research UK to give something back for the generous support that I have received from them over the years, and I would be massively grateful for any sponsorship and for generally helping to spread the word:

https://www.justgiving.com/fundraising/SJA-LEJOG-2022

Please remember to add Gift Aid if you are eligible - thank you! 

I also have another page for the Red Cross to show solidarity with the people of Ukraine and other countries who need humanitarian aid and support from the Disasters Emergency Committee.

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LIVER CANCER EVOLUTION CONSORTIUM (HYBRID) MEETING

01 February 2022

This week we hosted the Liver Cancer Evolution Consortium meeting at the MRC Toxicology Unit. A truly hybrid meeting, with attendees from Edinburgh, Barcelona, Heidelberg, Hinxton, and Cambridge.

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AND THEN THERE WERE FOUR!

12 January 2022

This week Hashim and Jose both joined our team.

L to R: (me), Hashim, Jose, and John.

Hashim Ahmed Nur is a MRC PhD student working on molecular and genomic responses to DNA damaging agents.

Jose Coehlo-Lima is a postdoctoral NIHR Academic Clinical Fellow, working on computational analysis of clinical histology images of lung cancers.

John Connelly is a Wellcome Trust Clinical PhD Student (University of Edinburgh). He is using machine learning to detect mutational processes in digitised pathology images of liver tumours.

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CAMBRIDGE HEPATOLOGY RESEARCH SEMINAR

14 December 2021

Sarah was invited to present our work on Lesion Segregation at the monthly Eastern Liver Network Cambridge Hepatology Research Seminar.

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EMBL CANCER GENOMICS

22 November 2021

Sarah presented the next instalment from the Liver Cancer Evolution Consortium at EMBL Cancer Genomics"Re-running cancer evolution in vivo: a high-resolution multi-omics approach"

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WE ARE HIRING: PHD STUDENT

16 November 2021

We are hiring: Phd studentship to join us in October 2022.

Characterisation of 3D liver models for discovery toxicology and pathology 

Deadline: 02 December 2021

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CRUK CAMBRIDGE INSTITUTE RETREAT

22 October 2021

Sarah was invited to present our work on Lesion Segregation at the CRUK Cambridge Institute annual retreat.

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WE ARE HIRING: PHD STUDENT

16 September 2021

We are hiring: Phd studentship to join us in January 2022.

Molecular and genomic responses to DNA damaging agents in the context of liver toxicity and disease

Deadline: 27 September 2021

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AITKEN LAB: DAY ONE

01 September 2021

First day at the Medical Research Council Toxicology Unit in the School of Biological Sciences at the University of Cambridge. 

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WE ARE HIRING: PHD STUDENT

04 June 2021

We are hiring: Phd studentship to join us in October 2021.

Molecular and genomic responses to DNA damaging agents in the context of liver toxicity and disease

Deadline: 18 June 2021

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02 June 2021

The Aitken Lab will open at the MRC Toxicology Unit, University of Cambridge in autumn 2021.

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