HIGHLIGHTS
STRAND-RESOLVED MUTAGENICITY OF DNA DAMAGE AND REPAIR
20 June 2022
Craig J. Anderson, Lana Talmane, Juliet Luft, Michael D. Nicholson, John Connelly, Oriol Pich, Susan Campbell, Vasavi Sundaram, Frances Connor, Paul A. Ginno, Liver Cancer Evolution Consortium, Núria López-Bigas, Paul Flicek, Colin A. Semple, Duncan T. Odom*, Sarah J. Aitken*, Martin S. Taylor*
bioRxiv 2022.06.10.495644
https://doi.org/10.1101/2022.06.10.495644
Read the #StrandInteractions tweetorial here.
CONVERGENT SOMATIC MUTATIONS IN METABOLISM GENES IN CHRONIC LIVER DISEASE
21 October 2021
Stanley W. K. Ng, Foad J. Rouhani, Simon F. Brunner, Natalia Brzozowska, Sarah J. Aitken, Ming Yang, Federico Abascal, Luiza Moore, Efterpi Nikitopoulou, Lia Chappell, Daniel Leongamornlert, Aleksandra Ivovic, Philip Robinson, Timothy Butler, Mathijs A. Sanders, Nicholas Williams, Tim H. H. Coorens, Jon Teague, Keiran Raine, Adam P. Butler, Yvette Hooks, Beverley Wilson, Natalie Birtchnell, Huw Naylor, Susan E. Davies, Michael R. Stratton, Iñigo Martincorena, Raheleh Rahbari, Christian Frezza, Matthew Hoare & Peter J. Campbell
Nature 2021;598:473–478
PERVASIVE LESION SEGREGATION SHAPES CANCER GENOME EVOLUTION
24 June 2020
Sarah J Aitken, Craig J Anderson, Frances Connor, Oriol Pich, Vasavi Sundaram, Christine Feig, Tim F Rayner, Margus Lukk, Stuart Aitken, Juliet Luft, Elissavet Kentepozidou, Claudia Arnedo-Pac, Sjoerd V Beentjes, Susan E Davies, Ruben M Drews, Ailith Ewing, Vera B Kaiser, Ava Khamseh, Erika López-Arribillaga, Aisling M Redmond, Javier Santoyo-Lopez, Inés Sentís, Lana Talmane, Andrew D Yates, Liver Cancer Evolution Consortium, Colin A Semple, Núria López-Bigas, Paul Flicek, Duncan T Odom, Martin S Taylor
Nature 2020;583(7815):265-270
https://doi.org/10.1038/s41586-020-2435-1
Strands of evidence about cancer evolution
CLUSTERED CTCF BINDING IS AN EVOLUTIONARY MECHANISM TO MAINTAIN TOPOLOGICALLY ASSOCIATING DOMAINS
07 January 2020
Elissavet Kentepozidou, Sarah J. Aitken, Christine Feig, Klara Stefflova, Ximena Ibarra-Soria, Duncan T. Odom, Maša Roller, Paul Flicek
Genome Biology. 2020;21:5
SOMATIC MUTATIONS AND CLONAL DYNAMICS IN HEALTHY AND CIRRHOTIC HUMAN LIVER
23 October 2019
Simon F Brunner, Nicola D Roberts, Luke A Wylie, Luiza Moore, Sarah J Aitken, Susan E Davies, Mathijs A Sanders, Pete Ellis, Chris Alder, Yvette Hooks, Federico Abascal, Michael R Stratton, Inigo Martincorena, Matthew Hoare, Peter J Campbell
Nature. 2019;574:538-542
MUTATIONAL LANDSCAPE OF A CHEMICALLY-INDUCED MOUSE MODEL OF LIVER CANCER
01 October 2018
Frances Connor, Tim F Rayner, Sarah J Aitken, Christine Feig, Margus Lukk, Javier Santoyo-Lopez, Duncan T Odom
Journal of Hepatology. 2018;69(4):840-850
CTCF MAINTAINS REGULATORY HOMEOSTASIS OF CANCER PATHWAYS
07 August 2018
Sarah J Aitken*, Ximena Ibarra-Soria*, Elissavet Kentepozidou, Paul Flicek, Christine Feig, John C Marioni, Duncan T Odom
*SJA and XIS contributed equally.
Genome Biology. 2018;19:106.
FULL LIST OF PUBLICATIONS AND PREPRINTS
2022
CJ Anderson, L Talmane, J Luft, MD Nicholson, J Connelly, O Pich, S Campbell, V Sundaram, F Connor, PA Ginno, Liver Cancer Evolution Consortium, N López Bigas, P Flicek, CA Semple, DT Odom*, SJ Aitken*, MS Taylor*. Strand-resolved mutagenicity of DNA damage and repair. bioRxiv. 2022.06.10.495644 https://doi.org/10.1101/2022.06.10.495644
HC Chen, N Mueller, K Stott, E Rivers, C Kapeni, CM Sauer, F Beke, S Walsh, N Ashman, L O’Brien, A Rafati Fard, A Godsinia, A Joud, I Giger, I Zlobec, I Olan, SJ Aitken, M Hoare, R Mair, E Serrao, JD Brenton, A Garcia-Gimenez, SE Richardson, B Huntly, DR Spring, MO Skjødt, K Skjødt, M de la Roche, M de la Roche. Novel therapeutic LGR5 antibodies targeting multiple cancer types. bioRxiv. 2022.09.01.506182 https://www.biorxiv.org/content/10.1101/2022.09.01.506182
J Wang, P Kotagiri, PA Lyons, RS Al-Lamki, F Mescia, L Bergamaschi, L Turner, MD Morgan, FJ Calero-Nieto, K Bach, N Mende, NK Wilson, ER Watts, PH Maxwell, PF Chinnery, N Kingston, S Papadia, KE Stirrups, N Walker, RK Gupta, DK Menon, KSJ Allinson, SJ Aitken, M Toshner, MP Weekes, JA Nathan, SR Walmsley, WH Ouwehand, M Kasanicki, B Göttgens, JC Marioni, KGC Smith, JS Pober, JR Bradley. Coagulation factor V is a T-cell inhibitor expressed by leukocytes in COVID-19. iScience. 2022;25:103971. https://doi.org/10.1016/j.isci.2022.103971
2021
SWK Ng, FJ Rouhani, SF Brunner, N Brzozowska, SJ Aitken, M Yang, F Abascal, L Moore, E Nikitopoulou, L Chappell, D Leongamornlert, A Ivovic, P Robinson, T Butler, MA Sanders, N Williams, THH Coorens, J Teague, K Raine, AP Butler, Y Hooks, B Wilson, N Birtchnell, H Naylor, SE Davies, MR Stratton, I Martincorena, R Rahbari, C Frezza, M Hoare, PJ Campbell. Convergent somatic mutations in metabolism genes in chronic liver disease Nature. 2021;598:473–478. https://doi.org/10.1038/s41586-021-03974-6
2020
SJ Aitken, CJ Anderson, F Connor, O Pich, V Sundaram, C Feig, TF Rayner, M Lukk, S Aitken, J Luft, E Kentepozidou, C Arnedo-Pac, SV Beentjes, SE Davies, RM Drews, A Ewing, VB Kaiser, A Khamseh, E López-Arribillaga, AM Redmond, J Santoyo-Lopez, I Sentís, L Talmane, AD Yates, Liver Cancer Evolution Consortium, CA Semple, N López-Bigas, P Flicek, DT Odom, MS Taylor. Pervasive lesion segregation shapes cancer genome evolution. Nature. 2020;583:265-270. https://doi.org/10.1038/s41586-020-2435-1
R Siersbæk, V Scabia, S Nagarajan, I Chernukhin, EK Papachristou, R Broome, SJ Johnston, SEP Joosten, AR Green, S Kumar, J Jones, S Omarjee, R Alvarez-Fernandez, S Glont, SJ Aitken, K Kishore, D Cheeseman, EA Rakha, C D’Santos, W Zwart, A Russell, C Brisken, JS Carroll. IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis. Cancer Cell. 2020;38(3):412-423. https://doi.org/10.1016/j.ccell.2020.06.007
E Kentepozidou, SJ Aitken, C Feig, K Stefflova, X Ibarra-Soria, DT Odom, M Roller, P Flicek. Clustered CTCF binding is an evolutionary mechanism to maintain topologically associating domains. Genome Biology. 2020;21:5. https://doi.org/10.1186/s13059-019-1894-x
2019
SF Brunner, ND Roberts, LA Wylie, L Moore, SJ Aitken, SE Davies, M Sanders, P Ellis, C Alder, Y Hooks, F Abascal, MR Stratton, I Martincorena, M Hoare, PJ Campbell. Somatic mutations and clonal dynamics in healthy and cirrhotic human liver. Nature. 2019;574:538-542. https://doi.org/10.1038/s41586-019-1670-9
2018
SJ Aitken*, X Ibarra-Soria*, E Kentepozidou, P Flicek, C Feig, JC Marioni, DT Odom. CTCF maintains regulatory homeostasis of cancer pathways. Genome Biology. 2018;19:106. *SJA and XIS contributed equally. https://doi.org/10.1186/s13059-018-1484-3
F Connor, TF Rayner, SJ Aitken, C Feig, M Lukk, J Santoyo-Lopez, DT Odom. Mutational landscape of a chemically induced mouse model of liver cancer. Journal of Hepatology. 2018;69(4):840-850. https://doi.org/10.1016/j.jhep.2018.06.009
I Quiros-Gonzalez, MR Tomaszewski, SJ Aitken, L Ansel-Bollepalli, LA McDuffus, M Gill, L Hacker, J Brunker, SE Bohndiek. Optoacoustics delineates murine breast cancer models displaying angiogenesis and vascular mimicry. British Journal of Cancer. 2018;118:1098-1106. https://doi.org/10.1038/s41416-018-0033-x
2016
C Ernst, J Pike, SJ Aitken, HK Long, N Eling, L Stojic L, MC Ward, F Connor, TF Rayner, M Lukk, RJ Klose, C Kutter, Odom DT. Successful Transmission and Transcriptional Deployment of a Human Chromosome via Mouse Male Meiosis. eLife 2016;5:pii:e20235. https://doi.org/10.7554/eLife.20235
2015
SJ Aitken, N Presneau, S Kalimuthu, P Dileo, F Berisha, R Tirabosco, MF Amary, AM Flanagan. Next generation sequencing is highly sensitive for the detection of beta-catenin mutations in desmoid-type fibromatoses. Virchows Archives. 2015;467(2):203-10. https://doi.org/10.1007/s00428-015-1765-0
SJ Aitken, N Presneau, B Khatri, AM Flanagan, B Clarke, WG McCluggage. Mutations in IDH1 and IDH2 are not present in sporadic ovarian sex cord-stromal tumours. Histopathology. 2015;66(6):897-8. https://doi.org/10.1111/his.12489
SJ Aitken, N Presneau, R Tirabosco, MF Amary, P O'Donnell, AM Flanagan. An NRAS mutation in a case of Erdheim Chester disease. Histopathology. 2015;66(2):316-9. https://doi.org/10.1111/his.12443
EARLIER
SJ Aitken, SP Langdon, DJ Harrison, JS Thomas, D Faratian. Quantitative analysis of changes in ER, PR & HER2 expression in primary breast cancer and matched nodal metastases. Annals of Oncology. 2010;21(6):1254-61. https://doi.org/10.1093/annonc/mdp427
D Faratian, SJ Aitken, JS Thomas, SP Langdon, DJ Harrison. Reply to: discordant expression of molecular markers between primary and nodal metastases: a histopathological manifestation of the 'self (stem cell)-seeding' nature of breast cancer disease? Annals of Oncology. 2010;21(6):1375. https://doi.org/10.1093/annonc/mdq046
SJ Aitken, E Landao-Bassonga, SH Ralston, AI Idris. β2-adrenoreceptor ligands regulate osteoclast differentiation in vitro by direct and indirect mechanisms. Archives of Biochemistry and Biophysics. 2009;482(1-2):96-103. https://doi.org/10.1016/j.abb.2008.11.012
Current list of publications: Google Scholar