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HIGHLIGHTS

 
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STRAND-RESOLVED MUTAGENICITY OF DNA DAMAGE AND REPAIR

20 June 2022

Craig J. Anderson, Lana Talmane, Juliet Luft, Michael D. Nicholson, John Connelly, Oriol Pich, Susan Campbell, Vasavi Sundaram, Frances Connor, Paul A. Ginno, Liver Cancer Evolution Consortium, Núria López-Bigas, Paul Flicek, Colin A. Semple, Duncan T. Odom*, Sarah J. Aitken*, Martin S. Taylor*

bioRxiv 2022.06.10.495644

https://doi.org/10.1101/2022.06.10.495644

Read the #StrandInteractions tweetorial here.

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CONVERGENT SOMATIC MUTATIONS IN METABOLISM GENES IN CHRONIC LIVER DISEASE

21 October 2021

Stanley W. K. Ng, Foad J. Rouhani, Simon F. Brunner, Natalia Brzozowska, Sarah J. Aitken, Ming Yang, Federico Abascal, Luiza Moore, Efterpi Nikitopoulou, Lia Chappell, Daniel Leongamornlert, Aleksandra Ivovic, Philip Robinson, Timothy Butler, Mathijs A. Sanders, Nicholas Williams, Tim H. H. Coorens, Jon Teague, Keiran Raine, Adam P. Butler, Yvette Hooks, Beverley Wilson, Natalie Birtchnell, Huw Naylor, Susan E. Davies, Michael R. Stratton, Iñigo Martincorena, Raheleh Rahbari, Christian Frezza, Matthew Hoare & Peter J. Campbell

Nature 2021;598:473–478


https://doi.org/10.1038/s41586-021-03974-6

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PERVASIVE LESION SEGREGATION SHAPES CANCER GENOME EVOLUTION

24 June 2020

Sarah J Aitken, Craig J Anderson, Frances Connor, Oriol Pich, Vasavi Sundaram, Christine Feig, Tim F Rayner, Margus Lukk, Stuart Aitken, Juliet Luft, Elissavet Kentepozidou, Claudia Arnedo-Pac, Sjoerd V Beentjes, Susan E Davies, Ruben M Drews, Ailith Ewing, Vera B Kaiser, Ava Khamseh, Erika López-Arribillaga, Aisling M Redmond, Javier Santoyo-Lopez, Inés Sentís, Lana Talmane, Andrew D Yates, Liver Cancer Evolution Consortium, Colin A Semple, Núria López-Bigas, Paul Flicek, Duncan T Odom, Martin S Taylor

Nature 2020;583(7815):265-270

https://doi.org/10.1038/s41586-020-2435-1

Nature - News and Views

Strands of evidence about cancer evolution

Nature Reviews Cancer - Research Highlight 

Strands of evolution

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CLUSTERED CTCF BINDING IS AN EVOLUTIONARY MECHANISM TO MAINTAIN TOPOLOGICALLY ASSOCIATING DOMAINS

07 January 2020

Elissavet Kentepozidou, Sarah J. Aitken, Christine Feig, Klara Stefflova, Ximena Ibarra-Soria, Duncan T. Odom, Maša Roller, Paul Flicek 

Genome Biology. 2020;21:5


https://doi.org/10.1186/s13059-019-1894-x

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SOMATIC MUTATIONS AND CLONAL DYNAMICS IN HEALTHY AND CIRRHOTIC HUMAN LIVER

23 October 2019

Simon F Brunner, Nicola D Roberts, Luke A Wylie, Luiza Moore, Sarah J Aitken, Susan E Davies, Mathijs A Sanders, Pete Ellis, Chris Alder, Yvette Hooks, Federico Abascal, Michael R Stratton, Inigo Martincorena, Matthew Hoare, Peter J Campbell

Nature. 2019;574:538-542

https://doi.org/10.1038/s41586-019-1670-9

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MUTATIONAL LANDSCAPE OF A CHEMICALLY-INDUCED MOUSE MODEL OF LIVER CANCER

01 October 2018

Frances Connor, Tim F Rayner, Sarah J Aitken, Christine Feig, Margus Lukk, Javier Santoyo-Lopez, Duncan T Odom

 Journal of Hepatology. 2018;69(4):840-850

https://doi.org/10.1016/j.jhep.2018.06.009

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CTCF MAINTAINS REGULATORY HOMEOSTASIS OF CANCER PATHWAYS

07 August 2018

Sarah J Aitken*, Ximena Ibarra-Soria*, Elissavet Kentepozidou, Paul Flicek, Christine Feig, John C Marioni, Duncan T Odom

*SJA and XIS contributed equally.

Genome Biology. 2018;19:106. 

https://doi.org/10.1186/s13059-018-1484-3

FULL LIST OF PUBLICATIONS AND PREPRINTS

2022

CJ Anderson, L Talmane, J Luft, MD Nicholson, J Connelly, O Pich, S Campbell, V Sundaram, F Connor, PA Ginno, Liver Cancer Evolution Consortium, N López Bigas, P Flicek, CA Semple, DT Odom*, SJ Aitken*, MS Taylor*. Strand-resolved mutagenicity of DNA damage and repair. bioRxiv. 2022.06.10.495644 https://doi.org/10.1101/2022.06.10.495644

HC Chen, N Mueller, K Stott, E Rivers, C Kapeni, CM Sauer, F Beke, S Walsh, N Ashman, L O’Brien, A Rafati Fard, A Godsinia, A Joud, I Giger, I Zlobec, I Olan, SJ Aitken, M Hoare, R Mair, E Serrao, JD Brenton, A Garcia-Gimenez, SE Richardson, B Huntly, DR Spring, MO Skjødt, K Skjødt, M de la Roche, M de la Roche. Novel therapeutic LGR5 antibodies targeting multiple cancer types. bioRxiv. 2022.09.01.506182 https://www.biorxiv.org/content/10.1101/2022.09.01.506182

J Wang, P Kotagiri, PA Lyons, RS Al-Lamki, F Mescia, L Bergamaschi, L Turner, MD Morgan, FJ Calero-Nieto, K Bach, N Mende, NK Wilson, ER Watts, PH Maxwell, PF Chinnery, N Kingston, S Papadia, KE Stirrups, N Walker, RK Gupta, DK Menon, KSJ Allinson, SJ Aitken, M Toshner, MP Weekes, JA Nathan, SR Walmsley, WH Ouwehand, M Kasanicki, B Göttgens, JC Marioni, KGC Smith, JS Pober, JR Bradley. Coagulation factor V is a T-cell inhibitor expressed by leukocytes in COVID-19. iScience. 2022;25:103971. https://doi.org/10.1016/j.isci.2022.103971

2021

SWK Ng, FJ Rouhani, SF Brunner, N Brzozowska, SJ Aitken, M Yang, F Abascal, L Moore, E Nikitopoulou, L Chappell, D Leongamornlert, A Ivovic, P Robinson, T Butler, MA Sanders, N Williams, THH Coorens, J Teague, K Raine, AP Butler, Y Hooks, B Wilson, N Birtchnell, H Naylor, SE Davies, MR Stratton, I Martincorena, R Rahbari, C Frezza, M Hoare, PJ Campbell. Convergent somatic mutations in metabolism genes in chronic liver disease Nature. 2021;598:473–478. https://doi.org/10.1038/s41586-021-03974-6

2020

SJ Aitken, CJ Anderson, F Connor, O Pich, V Sundaram, C Feig, TF Rayner, M Lukk, S Aitken, J Luft, E Kentepozidou, C Arnedo-Pac, SV Beentjes, SE Davies, RM Drews, A Ewing, VB Kaiser, A Khamseh, E López-Arribillaga, AM Redmond, J Santoyo-Lopez, I Sentís, L Talmane, AD Yates, Liver Cancer Evolution Consortium, CA Semple, N López-Bigas, P Flicek, DT Odom, MS Taylor. Pervasive lesion segregation shapes cancer genome evolution. Nature. 2020;583:265-270. https://doi.org/10.1038/s41586-020-2435-1


R Siersbæk, V Scabia, S Nagarajan, I Chernukhin, EK Papachristou, R Broome, SJ Johnston, SEP Joosten, AR Green, S Kumar, J Jones, S Omarjee, R Alvarez-Fernandez, S Glont, SJ Aitken, K Kishore, D Cheeseman, EA Rakha, C D’Santos, W Zwart, A Russell, C Brisken, JS Carroll. IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis. Cancer Cell. 2020;38(3):412-423. https://doi.org/10.1016/j.ccell.2020.06.007

E Kentepozidou, SJ Aitken, C Feig, K Stefflova, X Ibarra-Soria, DT Odom, M Roller, P Flicek. Clustered CTCF binding is an evolutionary mechanism to maintain topologically associating domains. Genome Biology. 2020;21:5. https://doi.org/10.1186/s13059-019-1894-x

2019

SF Brunner, ND Roberts, LA Wylie, L Moore, SJ Aitken, SE Davies, M Sanders, P Ellis, C Alder, Y Hooks, F Abascal, MR Stratton, I Martincorena, M Hoare, PJ Campbell. Somatic mutations and clonal dynamics in healthy and cirrhotic human liver. Nature. 2019;574:538-542. https://doi.org/10.1038/s41586-019-1670-9

2018

SJ Aitken*, X Ibarra-Sor­ia*, E Kentepozidou, P Flicek, C Feig, JC Marioni, DT Odom. CTCF maintains regulatory homeostasis of cancer pathways. Genome Biology. 2018;19:106. *SJA and XIS contributed equally. https://doi.org/10.1186/s13059-018-1484-3


F Connor, TF Rayner, SJ Aitken, C Feig, M Lukk, J Santoyo-Lopez, DT Odom. Mutational landscape of a chemically induced mouse model of liver cancer. Journal of Hepatology. 2018;69(4):840-850. https://doi.org/10.1016/j.jhep.2018.06.009


I Quiros-Gonzalez, MR Tomaszewski, SJ Aitken, L Ansel-Bollepalli, LA McDuffus, M Gill, L Hacker, J Brunker, SE Bohndiek. Optoacoustics delineates murine breast cancer models displaying angiogenesis and vascular mimicry. British Journal of Cancer. 2018;118:1098-1106. https://doi.org/10.1038/s41416-018-0033-x

2016

C Ernst, J Pike, SJ Aitken, HK Long, N Eling, L Stojic L, MC Ward, F Connor, TF Rayner, M Lukk, RJ Klose, C Kutter, Odom DT. Successful Transmission and Transcr­­iptional Deployment of a Human Chromosome via Mouse Male Meiosis. eLife 2016;5:pii:e20235. https://doi.org/10.7554/eLife.20235

2015

SJ Aitken, N Presneau, S Kalimuthu, P Dileo, F Berisha, R Tirabosco, MF Amary, AM Flanagan. Next generation sequencing is highly sensitive for the detection of beta-catenin mutations in desmoid-type fibromatoses. Virchows Archives. 2015;467(2):203-10. https://doi.org/10.1007/s00428-015-1765-0


SJ Aitken, N Presneau, B Khatri, AM Flanagan, B Clarke, WG McCluggage. Mutations in IDH1 and IDH2 are not present in sporadic ovarian sex cord-stromal tumours. Histopathology. 2015;66(6):897-8. https://doi.org/10.1111/his.12489


SJ Aitken, N Presneau, R Tirabosco, MF Amary, P O'Donnell, AM Flanagan. An NRAS mutation in a case of Erdheim Chester disease. Histopathology. 2015;66(2):316-9. https://doi.org/10.1111/his.12443

EARLIER

SJ Aitken, SP Langdon, DJ Harrison, JS Thomas, D Faratian. Quantitative analysis of changes in ER, PR & HER2 expression in primary breast cancer and matched nodal metastases. Annals of Oncology. 2010;21(6):1254-61. https://doi.org/10.1093/annonc/mdp427


D Faratian, SJ Aitken, JS Thomas, SP Langdon, DJ Harrison. Reply to: discordant expression of molecular markers between primary and nodal metastases: a histopathological manifestation of the 'self (stem cell)-seeding' nature of breast cancer disease? Annals of Oncology. 2010;21(6):1375. https://doi.org/10.1093/annonc/mdq046

SJ Aitken, E Landao-Bassonga, SH Ralston, AI Idris. β2-adrenoreceptor ligands regulate osteoclast differentiation in vitro by direct and indirect mechanisms. Archives of Biochemistry and Biophysics. 2009;482(1-2):96-103. https://doi.org/10.1016/j.abb.2008.11.012

Current list of publications: Google Scholar