RESEARCH
Investigating how DNA, cells, and tissues are damaged by the world around us, causing diseases including cancer.
Among the most critical - and yet least understood - stages of cancer formation are the earliest. To address this, our lab seeks to understand the causes and consequences of DNA damage in human health and disease, and how the resultant mutations and genome instability contribute to tumourigenesis.
DNA DAMAGE AND MUTAGENESIS
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​How do DNA repair enzymes interact following chemotherapy exposure?
SPATIAL BIOLOGY AND DIGITAL PATHOLOGY
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How does the spatial distribution of mutations vary in cancer ?
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Can we predict genotype (mutation) from phenotype (histology)?
GASTROINTESTINAL DISEASE AND CANCER
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How does the spatial distribution of mutations vary within tissues in patients with colorectal cancer?
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How to develop human-relevant models to test potential mutagens?
FUNDING
We are very grateful for the funding that makes our research possible.
MRC
NIHR
PATHOLOGICAL SOCIETY OF GREAT BRITAIN & IRELAND
ACADEMY OF MEDICAL SCIENCES
